Violations of antioxidant-prooxidant spleen index and ceruloplasmin content in serum during acute blood loss, complicated by ischemia-reperfusion of limb and the effectiveness of its correction with carbacetam

Antioxidant-prooxidant imbalance is one of the key mechanisms acute blood loss and ischemic-reperfusion syndrome. Under these conditions, level ceruloplasmin (CP) plays an important role, enhancing antioxidant protection promoting hematopoiesis, exhibiting ferrooxidase action. However, in this case, state antioxidant-prooxidant balance spleen content CP serum studied insufficiently, thus there no data on effectiveness carbacetam, which revealed a pronounced protective effect spleen.Objective research: to determine dynamics index complicated by ischemia-reperfusion limb, evaluate carbacetam correction identified disorders.Materials research their discussion. 108 nonlinear male rats weighing 200–220 g were used experiments. All experiments performed under thiopental-sodium anesthesia. In animals, limb modeled separately groups injuries combined. separate group, detected disorders corrected with carbacetam. After 1 2 hours, as well after 1, 7 14 days experimental animals was determined reagents thiobarbituric acid catalase activity, according results (API) calculated serum.Results Modeling loss, contributed decrease value API spleen, indicates shift antioxidant-prooxidation towards dominance prooxidant mechanisms. increases significantly, hand compensates lack protection, other activation body's systemic response inflammation. The use helped reduction serum, anti-inflammatory drug, its prospects cases connected hemic hypoxia syndrome.Conclusions: Complication contributes simultaneous increase serum. helps reduce